Mandible
A 35-year-old man has a multilocular radiolucent lesion in the posterior mandible.
What our notes say
- A 35-year-old man has a multilocular radiolucent lesion in the posterior mandible. (Master Bone & Soft Tissue Pathology: CAT 2 MCQs & Answers)
- Clinical picture: large everted ears, long face, large mandible, macroorchidism, intellectual disability (Clinical Genetics: Master Mendelian Disorders & Molecular Basis)
Practice questions on Mandible
Large everted ears, long face, large mandible, macroorchidism; multiple CGG tandem repeats.
- Fragile X syndrome
- Huntington's chorea
- Myotonic dystrophy
- Spinal-bulbar muscular atrophy
- Ataxia-telangiectasia
Answer: A. Classic Fragile X syndrome phenotype and FMR1 CGG expansion. ---
A 35-year-old man has a multilocular radiolucent lesion in the posterior mandible. Histology demonstrates a keratinised stratified squamous epithelial lining with a corrugated surface. Which diagnosis is most likely?
- Dentigerous cyst
- Radicular cyst
- Keratocystic odontogenic tumour
- Osteoma
- Ameloblastoma
Answer: C. A multilocular radiolucent lesion with a keratinized stratified squamous epithelial lining and corrugated surface is pathognomonic for a Keratocystic Odontogenic Tumour (KCOT).