Chronic Granulomatous Disease
Also written as CGD.
Leprosy (Hansen’s disease) is a chronic granulomatous disease
What our notes say
- Leprosy (Hansen’s disease) is a chronic granulomatous disease (Davidson's Essentials of Medicine - 2nd)
- Systemic amyloidosis is due to disseminated deposition of amyloid plaques, e.g. in chronic granulomatous disease (Medical MCQs: Chemical Pathology & Haematology Exam Review — MCQ Bank)
- M. tuberculosis is an acid-fast, aerobic bacillus that causes chronic granulomatous disease. (MBMM 3311 Medical Bacteriology Examination — Notes)
- Tuberculosis: A communicable chronic granulomatous disease caused by Mycobacterium tuberculosis, characterized by granuloma formation and potential for cavitation. (Lung Pathology — Must-Know — Notes)
- A communicable chronic granulomatous disease caused by _Mycobacterium tuberculosis_. (Lung Pathology — Must-Know — Notes)
- of neutrophil function such as chronic granulomatous disease (Devendra K. Gupta, Krishna M. Goel - Hutchison’s Paediatrics. chdhe-Jaypee Broth)
Study material on Chronic Granulomatous Disease
- Comprehensive Immunology Quiz — Killing Mechanisms, Vaccines — MCQ Bank
- Inflammation and Tissue Repair — MCQ Bank
- Devendra K. Gupta, Krishna M. Goel - Hutchison’s Paediatrics. chdhe-Jaypee Brothers (2012)
- Kaplan Pediatrics pdf-notes 201506051322 - flattened (2)
- Comprehensive Immunology Quiz — T Cell Development, Memory & Innate — MCQ Bank
Practice questions on Chronic Granulomatous Disease
Which cellular process is impaired in patients with chronic granulomatous disease?
- Apoptosis of neutrophils
- Generation of superoxide by leukocytes
- Phagocytosis of bacteria
- Chemotaxis toward infection sites
Answer: B. Chronic granulomatous disease results from defects in NADPH oxidase, which is required for the respiratory burst that generates superoxide (O2•−) in leukocytes. This impairs their ability to kill phagocytosed microbes, leading to recurrent infections. ## SECTION 5: OTHER MECHANISMS OF CELL DEATH