Clinical Diseases

Human Papillomavirus (HPV) and Parvovirus B19 are both non-enveloped DNA viruses that cause important clinical diseases.

What our notes say

Human Papillomavirus (HPV) and Parvovirus B19 are both non-enveloped DNA viruses that cause important clinical diseases. (EXAM: Bacteriophages, Laboratory Diagnosis, HPV & Parvovirus B19)
This explains why there is little structural damage on pathology despite severe clinical disease (EXAM: Vaccines & Antivirals, Rabies, CMV & EBV, Adenovirus & Enteroviruses)
Clinical disease is largely immune-mediated — the T cell response causes symptoms (EXAM: Vaccines & Antivirals, Rabies, CMV & EBV, Adenovirus & Enteroviruses)
Virus is neutralised before clinical disease can develop (MKU Medical Virology Exam Guide: HIV, CMV, Vaccines & More)
While most flagellates are harmless, some, like Giardia lamblia and Trichomonas vaginalis, are responsible for clinical diseases. (Parasitic Protozoa)
Management: post-exposure prophylaxis (PEP) — wound washing + rabies immunoglobulin (passive) + rabies vaccine series (active) — must be given before symptom onset, as no treatment exists once clinical disease starts (VIROLOGY SEM 3 CRASHED)