DNA Replication
The following is NOT correctly matched to their role in DNA replication
DNA Replication
- DNA replication is the process by which DNA makes an exact copy of itself. This process occurs before cell division to ensure that each daughter cell receives a complete and identical set of genetic material.
Read this in Tertiary Structure of DNA
What our notes say
- The following is NOT correctly matched to their role in DNA replication (Biochemistry End of Year Exam — 2014 (Past Paper))
- The result is selective inhibition of viral replication with minimal toxicity to host DNA replication (Medical Mycology Q&A Section C)
- G2/M checkpoint — confirms DNA replication is complete before mitosis (Hallmarks of Cancer: Molecular Basis, Cell Cycle & Oncogenes)
- G2/M checkpoint → ensures DNA replication is complete before mitosis (Molecular Basis of Cancer: Cell Cycle, Apoptosis & Angiogenesis)
- These enzymes are essential for DNA replication, transcription, and repair. (Basic Pharmacology - Study Guide)
- Fluoroquinolones inhibit bacterial DNA gyrase (topoisomerase II) and topoisomerase IV enzymes, which are essential for DNA replication, transcription, and chromosomal segregation. (Basic Pharmacology - Study Guide)
Study material on DNA Replication
- Dna Replication
- Tertiary Structure of DNA
- Molecular Biology Exam Review MCQs
- Molecular Biology,Molecular Genetics & Microbial-Biochemistry MCQs
- Polymerase Chain Reaction (PCR)
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- Basic Pharmacology - Study Guide
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Practice questions on DNA Replication
Which of the following is important in maintaining DNA replication fidelity?
- DNA polymerase 3'–5' proofreading enzyme
- RNA polymerase 3'–5' proofreading enzyme
- Thymine dimer exonuclease
- None of the above
- B and C
Answer: A. DNA polymerase has 3'-5' exonuclease activity (proofreading function) that removes incorrectly incorporated nucleotides, ensuring high fidelity during DNA replication. ---
DNA replication in Polymerase Chain Reaction is catalyzed by
- Topoisomerases
- RNA polymerase
- Taq DNA polymerase
- Taq RNA polymerase
- DNA polymerase
Answer: E. PCR uses Taq DNA polymerase, a thermostable enzyme from Thermus aquaticus that can withstand the high temperatures required for PCR cycling. ---