Transcription
HBV is a DNA virus that replicates by reverse transcription of an RNA intermediate.
What our notes say
- HBV is a DNA virus that replicates by reverse transcription of an RNA intermediate. (Paediatrics end of 2nd semester exam (MBPE 4300): 5 October 2021, 50 MCQs)
- Mechanism: T4 is converted to T3, which binds nuclear thyroid hormone receptors and raises gene transcription, metabolic rate, heart rate and thermogenesis. (Integrated case paper: Medicine, Surgery, Gynaecology and Paediatrics (160 marks)
- The DNA site at which transcription commences is exposed by the action of: (cat 2 2014 — Source Paper Awaiting Edit)
- Is an organelle that participates in transcription and translation (cat 2 2014 — Source Paper Awaiting Edit)
- Eventually, the transcription rates of specific mRNAs are affected (Physio Y1 EOY 2021 — Past Paper Questions & Answers)
- State four functions of nucleotides in humans with one example each; draw and label a cytosolic ribosome; explain why the genetic code is degenerate; state permitted wobble base-pairing; and complete the supplied transcription/translation sequence table. (bchem EOY 2011 — Past Paper Questions & Answers)
Study material on Transcription
- Transcription Factors
- Inhibitors of Transcription
- 🔹 Eukaryotic Transcription & Translation
- Introduction To Genetics
- Inhibitors of Translation
- Medical Physiology Assorted SAQs — With Answers (Past Paper Study Guide)
- ONCOPATHOLOGY - 30 KEY SHORT ANSWER QUESTIONS Hallmarks 1,2 & 3
- Types of Mutations in ARBHN (Amino Acid Replacement Based on Hemoglobin to Product Form)
- bchem EOY 2011
- bchem EOY 2011 (2)
- Transcription Factors and Gene Regulation
- Gene Transfer and Transcription in Bacteria
- ONCOPATHOLOGY MCQ EXAMINATION HAllmarks of Cancer 1,2 &3
- TUMOR SUPPRESSOR GENES & CELL CYCLE CONTROL MCQs
- Pathology by Dr. Irungu
- Weekly Pathology Exam - July 24, 2026 (Section A: MCQs)
Practice questions on Transcription
In eukaryotes, transcription and translation occur in...
- Both occur in the cytosol
- Nucleus and Ribosome respectively
- Cytosol and Nucleus respectively
- Nucleus and Cytosol respectively
- Ribosome and Nucleus respectively
Answer: D. In eukaryotes, transcription occurs in the nucleus where DNA is located, and translation occurs in the cytosol on ribosomes. This spatial separation allows for RNA processing before translation. ---
Which transcription factor gene is suspected to be responsible for 22q11.2 deletion syndrome?
- PAX1
- TBX1
- HOX1
- SOX1
- Mostly unchanged in early disease
Answer: B. The transcription factor gene TBX1 is suspected to be responsible for 22q11.2 deletion syndrome, as its loss seems to correlate with the occurrence of DiGeorge syndrome. ---
Which event would MOST effectively prevent E2F-mediated transcription of S-phase genes?
- Activation of CDK2-cyclin E complex
- Hyperphosphorylation of RB protein
- Hypophosphorylation of RB protein
- Degradation of p21 protein E.
Answer: C. Hypophosphorylated RB binds to and sequesters E2F, preventing transcription. Hyperphosphorylation releases E2F, allowing transcription to proceed. ---
The primary function of activated E2F transcription factor is to
- Inhibit DNA synthesis
- Promote degradation of cyclins
- Transcribe genes essential for S phase progression
- Phosphorylate RB protein
Answer: C. When released from RB, E2F transcribes genes required for S phase, including cyclin E and DNA polymerases, driving DNA synthesis and cell cycle progression. ---
Which transcription factor gene is suspected to be responsible for 22q11.2 deletion syndrome?
- PAX1
- TBX1
- HOX1
- SOX1
Answer: B. ** The transcription factor gene TBX1 is suspected to be responsible for the clinical features. ---
Which transcription factor mutation is specifically linked to DiGeorge syndrome and neural crest migration?
- NKX2.5
- TBX1
- GATA4
- NOTCH1
Answer: B. TBX1 mutation is specifically linked to DiGeorge syndrome, which involves defective neural crest migration. ---