Second Messengers
Select one: 1.00 a. are not part of any second messenger cascade
Second Messengers
- Second messengers are critical intracellular signaling molecules that transmit signals from activated receptors on the cell surface to target molecules within the cell's interior. They amplify and distribute the signal, leading to a coordin
Read this in LECTURE 2B: Signal Transduction and Second Messengers
What our notes say
- Select one: 1.00 a. are not part of any second messenger cascade (Physio Y1 EOY 2021 — Past Paper Questions & Answers)
- Second messengers are molecules that relay signals received of receptors on the cell surface to target molecules in the cytosol and/or nucleus. (Medical Physiology Assorted SAQs — With Answers (Past Paper Study Guide))
- (b) Name five second messengers and the ligands that are associated with their pathway. (Medical Physiology Assorted SAQs — Set 2 (Past Paper))
- (c) Explain what a second messenger is and how it is formed. (5 marks) (Medical Physiology End of Semester 1 Exam — March 2019 (Past Paper))
- When a hormone uses a second messenger, the next step after binding is:A) Phosphodiesterase activation (Biochemical Endocrinology, MBMB2234: Neurochemistry)
- When a hormone that uses a second messenger binds to a target cell, the next thing that happens is that: (Endocrine and Metabolic Pathology MCQs)
Study material on Second Messengers
- LECTURE 2B: Signal Transduction and Second Messengers
- Endocrine and Metabolic Pathology MCQs
- Medical Physiology Assorted SAQs — With Answers (Past Paper Study Guide)
- Medical Physiology Assorted SAQs — Set 2 (Past Paper)
- cat 2 2014 — Source Paper Awaiting Edit
- Physio Y1 EOY 2021
- Medical Physiology End of Semester 1 Exam — March 2019 (Past Paper)
- Biochemical Endocrinology, MBMB2234: Neurochemistry
- Endocrine and Metabolic Pathology MCQs for Medical Students
- LECTURE 6: Pancreatic and Adrenal Hormones
- Signal Transduction and Second Messengers
Practice questions on Second Messengers
: Which G-protein and second messenger system is activated by 5-HT2 receptors?
- Gs → cAMP increase
- Gi → cAMP decrease
- Gq → IP3 and DAG increase
- Direct ion channel opening
Answer: C. 5-HT2 receptors (including 5-HT2A, 5-HT2B, 5-HT2C) couple to Gq proteins, activating phospholipase C to produce IP3 (releases Ca2+) and DAG (activates PK ---
The primary second messenger for Beta-receptor signaling is:
- IP3
- DAG
- cAMP
- cGMP
Answer: C. Beta receptors are coupled to Gs proteins, which activate adenylyl cyclase to increase cAMP.