Transcription Factors
PU.1 is the master transcription factor tipping multipotent progenitors toward myeloid fate while suppressing lymphoid genes.
What our notes say
- PU.1 is the master transcription factor tipping multipotent progenitors toward myeloid fate while suppressing lymphoid genes. (Haematopathology MCQs: Blood Disorders & Anemia Explained)
- *RB normally binds and inhibits E2F transcription factors, blocking the G1/S transition until the cell is ready to divide. (General Pathology MCQs: Cancer, Tumors & Molecular Path Review)
- Pathogenesis — the principal defect is a block in differentiation caused by acquired mutations in lineage-specific transcription factors: (White Cell Disorders — Must-Know Notes)
- The receptors function as ligand-dependent transcription factors. (Medical Physiology Assorted SAQs — With Answers (Past Paper Study Guide))
- E7 binds and inactivates the retinoblastoma (Rb) protein, releasing E2F transcription factors and driving uncontrolled cell cycle progression (Skin & Breast Pathology MCQs: Dermatological Lesions & Diseases)
- Chromosomal translocation producing fusion transcription factor (General Pathology MCQs: Cancer, Tumors & Molecular Path Review)
Study material on Transcription Factors
- Transcription Factors
- ONCOPATHOLOGY - MCQs WITH EXPLANATIONS
- ONCOPATHOLOGY - 30 KEY SHORT ANSWER QUESTIONS Hallmarks 1,2 & 3
- Hallmarks of Cancer: Molecular Basis, Cell Cycle & Oncogenes
- Introduction To Genetics
- General Pathology MCQs: Cancer, Tumors & Molecular Path Review
- Genetic Disorders Pathology Crash Course: Exam Revision Notes
- Biochemical Endocrinology, MBMB2234: Neurochemistry
- Endocrine and Metabolic Pathology MCQs: Practice Questions
- Transcription Factors and Gene Regulation
Practice questions on Transcription Factors
Which transcription factor gene is suspected to be responsible for 22q11.2 deletion syndrome?
- PAX1
- TBX1
- HOX1
- SOX1
- Mostly unchanged in early disease
Answer: B. The transcription factor gene TBX1 is suspected to be responsible for 22q11.2 deletion syndrome, as its loss seems to correlate with the occurrence of DiGeorge syndrome. ---
The primary function of activated E2F transcription factor is to
- Inhibit DNA synthesis
- Promote degradation of cyclins
- Transcribe genes essential for S phase progression
- Phosphorylate RB protein
Answer: C. When released from RB, E2F transcribes genes required for S phase, including cyclin E and DNA polymerases, driving DNA synthesis and cell cycle progression. ---
Which transcription factor gene is suspected to be responsible for 22q11.2 deletion syndrome?
- PAX1
- TBX1
- HOX1
- SOX1
Answer: B. ** The transcription factor gene TBX1 is suspected to be responsible for the clinical features. ---
Which transcription factor mutation is specifically linked to DiGeorge syndrome and neural crest migration?
- NKX2.5
- TBX1
- GATA4
- NOTCH1
Answer: B. TBX1 mutation is specifically linked to DiGeorge syndrome, which involves defective neural crest migration. ---
What transcription factor does hypophosphorylated RB bind to?
- p53
- E2F
- NF-κB
- AP-1
- Limited to a single tissue compartment
Answer: B. Hypophosphorylated Rb binds to E2F transcription factor, preventing E2F from activating transcription of genes required for cell cycle progression and DNA replication. ---
Tumor hypoxia stimulates VEGF expression through stabilization of which transcription factor?
- HIF-1α
- NF-κb
- MYC
- SMAD4
- p21
Answer: A. Under hypoxic conditions, HIF-1α is stabilized and promotes the transcription of VEGF, leading to angiogenesis.