Alkylating Agents

Also written as CCNS.

Direct-acting agents: act without metabolic conversion, e.g. alkylating agents (cyclophosphamide) - associated with leukaemia.

What our notes say

Direct-acting agents: act without metabolic conversion, e.g. alkylating agents (cyclophosphamide) - associated with leukaemia. (Eoy paper 2 gen systemic Patho 2025 — Past Paper Questions & Answers)
Direct-acting agents: alkylating agents (e.g. cyclophosphamide, busulfan) — associated with treatment-related acute myeloid leukaemia. (General & Systemic Pathology SAQ Paper II — 15 July 2025 (MBPA 3500, MKU Year 3,)
History of prior chemotherapy/radiotherapy (alkylating agent exposure) with a latency of several years, complex karyotype, and blast count ≥20% (35%) confirms t-AML, which carries a notably poor prognosis with standard treatment. (Haematopathology MCQs: Blood Disorders & Anemia Explained)
It belongs to a class of naturally-derived antibiotics repurposed for chemotherapy, distinct from alkylating agents or antimetabolites. (Pharmacology END SEM 3CAT: Drug Response, Bioavailability & Antifungals)
Include some anticancer medications used in chemotherapy regimens, e.g. alkylating agents, that may cause a subsequent, second form of cancer (Oncopathology MCQs: Test Your Knowledge on Cancer Pathology)
Alkylating agents, antitumor antibiotics, platinum compounds (Pharmacology CRASH Course)