Hypercoagulable State
Hypercoagulable state: fibrinogen and factors VII, VIII, X rise, and fibrinolysis is reduced.
What our notes say
- Hypercoagulable state: fibrinogen and factors VII, VIII, X rise, and fibrinolysis is reduced. (Reproductive Health 1 End of Trimester CAT: ectopic pregnancy, ANC and abortion )
- Clotting: Factors V, VII, VIII, IX, X, XII, von Willebrand factor and fibrinogen (doubles) rise; antithrombin III and protein S fall; fibrinolysis is reduced — A hypercoagulable state: protects against postpartum haemorrhage but raises the risk of venous thromboembolism (Physiological changes in pregnancy)
- Arterial thromboembolism is usually responsible\nbut colonic ischaemia can also follow severe hypotension, colonic\nvolvulus, strangulated hernia, systemic vasculitis, aortic aneurysm\nsurgery or hypercoagulable states. (Davidson's Essentials of Medicine - 2nd)
- Right-sided Leiden is higher than that of all other identified inherited\neffusions are more common than left-sided effusions in hypercoagulable states combined, including deficiencies\nheart failure. (Harrisons Pulmonary and Critical Care Medicine)
- This is known as Thrombophilia (Hypercoagulable state). (Hypercoagulable state (1))
- The hypercoagulable state is due to loss of\nclotting factors (e.g. antithrombin) in the urine and an increase in hepatic production of fibrinogen.\nProlonged bed rest should be avoided, as thromboembolism is very common (particularly in\nmembranous nephropathy). (L20- Glomerular diseases)
Study material on Hypercoagulable State
Practice questions on Hypercoagulable State
Which natural anticoagulant is physiologically reduced in pregnancy, contributing to a hypercoagulable state?
- Protein C
- Protein S
- Antithrombin III
- Plasminogen
Answer: B. Free Protein S levels fall in pregnancy due to increased binding protein, reducing its anticoagulant activity and contributing to venous thromboembolism risk.