Sclerosing Cholangitis
Also written as SC.
\n\n HIV cholangiopathy: A sclerosing cholangitis is seen in patients\nwith severe immune suppression.
What our notes say
- \n\n HIV cholangiopathy: A sclerosing cholangitis is seen in patients\nwith severe immune suppression. (Davidson's Essentials of Medicine - 2nd)
- Ulcerative colitis raises the risk of colorectal cancer and primary sclerosing cholangitis. (Endocrinology and Gastroenterology Question Bank: 12 Clinical MCQs)
- Hepatobiliary tree: Primary sclerosing cholangitis linked to UC (Inflammatory bowel disease)
- Extra‑intestinal: primary sclerosing cholangitis, ankylosing spondylitis, uveitis, thromboembolic events, nutritional deficiencies (vit B12, iron, folate). (Inflammatory bowel disease)
- Hepatobiliary: Primary sclerosing cholangitis, cholestasis, gallstone disease — Impaired bile‑acid delivery → fat malabsorption (Malabsorption)
- Risk factors: primary sclerosing cholangitis, liver flukes (*Opisthorchis viverrini* and *Clonorchis sinensis*), choledochal cysts, hepatolithiasis, Thorotrast. (Liver tumours: benign, primary malignant and metastatic)
Study material on Sclerosing Cholangitis
- Davidson's Essentials of Medicine - 2nd
- 2.BILIARY TRACT DISEASE
- BILIARY TRACT DISEASE
- 04 gastroenterology mcqs
- Gastrointestinal and liver
- Inflammatory bowel disease
- GASTROINTESTINAL PATHOLOGY (Part 2) — Notes
- Liver Histology and Physiology: Structural Units and Acinar Zones — Notes
Practice questions on Sclerosing Cholangitis
A 70-year-old man with Primary Sclerosing Cholangitis (PSC) develops jaundice and an intrahepatic mass with normal AFP. Which primary liver malignancy is most consistent?
- Cholangiocarcinoma
- Hepatocellular Carcinoma
- Angiosarcoma
- Hepatoblastoma
Answer: A. Cholangiocarcinoma arises from the bile duct epithelium. Risk factors include PSC, liver flukes, and Caroli disease. AFP is usually normal, but CA 19-9 may be elevated.
A 70-year-old man with a history of Primary Sclerosing Cholangitis (PSC) develops jaundice and an intrahepatic mass. His serum alpha-fetoprotein (AFP) level is within the normal range. Which primary liver malignancy is most consistent with this presentation?
- Hepatocellular Carcinoma
- Fibrolamellar HCC
- Angiosarcoma
- Cholangiocarcinoma
Answer: D. Cholangiocarcinoma is a bile duct origin tumor associated with PSC and is characterized by a normal AFP level, differentiating it from typical HCC.