Viral Hepatitis

Q: Which zone is most affected by viral hepatitis (non-specific)?

Zone 1. While hepatitis can be diffuse, early involvement often targets Zone 1 due to blood flow dynamics, though Zone 3 is often cited for toxins.

Bilirubin is mixed, with an unconjugated majority (70 of 85 µmol/L), and the cause is likely acute viral hepatitis, so I would check hepatitis A, B and C serology.

What our notes say

Bilirubin is mixed, with an unconjugated majority (70 of 85 µmol/L), and the cause is likely acute viral hepatitis, so I would check hepatitis A, B and C serology. (Chemical Pathology Practice Examination)
Typhoid fever, pyelonephritis or other sepsis, viral hepatitis, and HIV-related infections. (Junior Clerkship in Reproductive Health (MBOG 4200): end of year examination, 4 )
Viral hepatitis: check hepatitis B surface antigen and hepatitis C antibody (Treatment of Infectious Disease: 5-case clinical quiz)
| Hepatocellular | ALT and AST high | Viral hepatitis, drugs, alcohol, autoimmune hepatitis | (Hepatitis B and the approach to hepatitis)
Causes: chronic alcohol use, chronic viral hepatitis (B and C), non-alcoholic fatty liver disease, autoimmune hepatitis (Pathology Practical Revision Guide)
Clinically confused with other causes of febrile jaundice: malaria, viral hepatitis A, B and E, leptospirosis, and other viral haemorrhagic fevers such as dengue, Lassa and Ebola (Medical Virology CAT 2024/2025 — MKU MBMM 3333 Questions & Answers)

Study material on Viral Hepatitis

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Practice questions on Viral Hepatitis

Which zone is most affected by viral hepatitis (non-specific)?

Zone 1
Zone 2
Zone 3
All zones

Answer: A. While hepatitis can be diffuse, early involvement often targets Zone 1 due to blood flow dynamics, though Zone 3 is often cited for toxins.