Liver Disease
The duration of action of procaine is increased in liver disease
What our notes say
- The duration of action of procaine is increased in liver disease (Clinical Pharmacology I (MBPL 4400) main exam: 25 January 2023)
- Liver disease is typically associated with megaloblastic macrocytosis (Internal Medicine End of Semester CAT (MBChB 4): haematology and renal, 30 MCQs )
- By the history, the option closest to alcoholic liver disease is E. (Internal Medicine CAT 1 (MBChB 4), 2022: liver, pancreas and bone marrow, 30 MCQ)
- | Medically ill patients | Adjust for kidney and liver disease; check heart disease and QT prolongation; consider interactions with other drugs. | (Introduction to Psychopharmacology)
- Alpha-1 antitrypsin deficiency (young, lower-zone emphysema, family history, liver disease). (Chronic Obstructive Pulmonary Disease (COPD))
- The stigmata of chronic liver disease in childhood include all of the following EXCEPT: (Paediatrics end of 2nd semester exam (MBPE 4300): 5 October 2021, 50 MCQs)
Study material on Liver Disease
- Internal Medicine 4th Year 1st Semester CAT: HIV and the gut, liver disease and pancreatitis, 30 MCQs and 2 short answers
- Chemical Pathology MCQs: Diabetes, Renal & Liver Disease
- Liver Histology & Physiology
- Liver Histology & Physiology
- Chemical Pathology Practice Examination
- CLINICAL BIOCHEMISTRY LAQs & SAQs
- CRUSH COURSE (PART 2) Clinical Chem Patho
- Liver Function Tests (LFTs)
- Liver Histology, Physiology and Pathology
- CRUSH COURSE YEAR 3 SEM 1 WORK (Part 1)
- Liver Histology, Physiology and Pathology — Practice Questions
- Liver Histology, Physiology and Pathology — Practice Questions
- Liver Histology, Physiology and Pathology — Practice Questions
- Liver Histology, Physiology and Pathology — Practice Questions
- Liver Histology, Physiology and Pathology — Practice Questions
- Liver Histology, Physiology and Pathology — Practice Questions
Practice questions on Liver Disease
A 58-year-old female presents with multiple bilateral liver lesions. She has no history of chronic liver disease. What is the most common diagnosis for malignant liver tumors in adults?
- Primary Hepatocellular Carcinoma
- Metastatic Carcinoma
- Primary Cholangiocarcinoma
- Angiosarcoma
Answer: B. Metastatic disease (especially from colon, lung, or breast) is far more common than primary liver cancer in non-cirrhotic livers. ---
A 50-year-old female with a history of chronic hepatitis C develops ascites and esophageal varices. Liver biopsy shows micronodular cirrhosis. What is the most likely complication leading to this advanced liver disease?
- Hepatitis B co-infection
- Alcoholic liver disease
- Non-alcoholic fatty liver disease (NAFLD)
- Hepatocellular carcinoma
Answer: A. While chronic Hepatitis C is a direct cause of cirrhosis, co-infection with Hepatitis B can accelerate the progression to cirrhosis and hepatocellular carcinoma. In the context of already advanced disease, it's a significant factor that would have contributed to the severity and progression. ---
A 58-year-old female presents with multiple bilateral liver lesions identified on CT scan. She has no known history of chronic liver disease or primary liver tumors. What is the most common diagnosis for malignant liver tumors in adults?
- Hepatocellular Carcinoma
- Cholangiocarcinoma
- Metastatic Carcinoma
- Liver Cell Adenoma
Answer: C. Metastatic carcinoma (secondary liver cancer) is the most common hepatic malignancy overall, far outnumbering primary liver tumors. ---
A patient presents with progressive liver disease, Kayser-Fleischer rings, neuropsychiatric symptoms, low caeruloplasmin, and elevated 24-hour urine copper. What is the diagnosis?
- Menkes disease
- Haemochromatosis
- Alpha-1 antitrypsin deficiency
- Wilson's disease
Answer: D. Wilson's disease is an autosomal recessive disorder of copper metabolism caused by mutations in the ATP7B gene. It leads to copper accumulation in the liver, basal ganglia, and cornea (Kayser-Fleischer rings), resulting in liver disease, neurological/psychiatric symptoms, and elevated urinary copper excretion. Caeruloplasmin levels are typically low. ---