Acute Interstitial Nephritis
Also written as AIN.
Characterised by FENa >2% and muddy brown granular casts. - AIN (Acute Interstitial Nephritis): Often a drug hypersensitivity reaction (e.g., NSAIDs, penicillins).
What our notes say
- Characterised by FENa >2% and muddy brown granular casts. - AIN (Acute Interstitial Nephritis): Often a drug hypersensitivity reaction (e.g., NSAIDs, penicillins). (Endocrine & Renal Pathology — Must Know Notes)
- Interstitial: acute interstitial nephritis (drugs such as NSAIDs and antibiotics), infection (pyelonephritis). (Junior Clerkship in Internal Medicine (MBIM4100) main exam, Paper One: 31 Januar)
- Interstitial: acute interstitial nephritis (drugs, infection), and pyelonephritis. (Paediatrics end of fourth year main exam: 1 July 2019, Paper One, 99 of 100 MCQs)
- | Acute interstitial nephritis (AIN) | Recent drug (penicillins, PPIs, NSAIDs) or infection; fever, rash, eosinophilia; white‑cell casts | Eosinophiluria on Hansel stain; urine may be sterile; FeNa variable but often >1 %. | (Acute kidney injury)
- | Acute interstitial nephritis | Drug exposure, eosinophilia, rash, fever | Steroid responsive; dialysis only for severe AKI features | (Indications for dialysis)
- Look‑alike conditions: differentiate pyelonephritis from renal colic (flank pain + hematuria, no systemic signs) and from acute interstitial nephritis (eosinophilia, rash, recent drug). (Urinary tract infection and pyelonephritis)
Study material on Acute Interstitial Nephritis
- Endocrine & Renal Pathology — Must Know Notes
- renal pathology
- Acute Tubular Injury (ATI): AKI Causes, Pathology & Prognosis