Mixed Connective Tissue Disease
Also written as MCTD.
Usually this is due to\nglomerular disease, although interstitial nephritis may also occur in\noverlap syndromes (e.g. mixed connective tissue disease, Sjögren’s\nsyndrome).
What our notes say
- Usually this is due to\nglomerular disease, although interstitial nephritis may also occur in\noverlap syndromes (e.g. mixed connective tissue disease, Sjögren’s\nsyndrome). (Davidson's Essentials of Medicine - 2nd)
- | Mixed connective tissue disease | Overlap of SLE, scleroderma, polymyositis features | High anti‑U1 RNP titre, prominent Raynaud’s, less renal disease. | (Systemic lupus erythematosus)
- Look‑alike conditions: drug‑induced lupus (hydralazine, procainamide), mixed connective tissue disease, dermatomyositis, infection‑related vasculitis. (Systemic lupus erythematosus)
- | Mixed connective tissue disease | Overlap of SLE, polymyositis, scleroderma features; high anti‑U1 RNP | Prominent myositis and Raynaud’s but skin fibrosis less extensive; serology differs. | (Systemic sclerosis)
- *CREST* vs. *mixed connective tissue disease* (presence of anti‑U1 RNP, more prominent myositis). (Systemic sclerosis)
- Autoimmune / rheumatic: Systemic lupus erythematosus, rheumatoid arthritis, Sjögren’s, mixed connective tissue disease — Auto‑antibody mediated vessel injury (Vasculitis)
Study material on Mixed Connective Tissue Disease
- Harrisons Cardiovascular Medicine 2nd Edition 2
- Devendra K. Gupta, Krishna M. Goel - Hutchison’s Paediatrics. chdhe-Jaypee Brothers (2012)
- Immunopathology complete MCQs
- Immunopathology