Nitric Oxide
Also written as NO.
Cause-finding: HIV test, immunoglobulins, sweat chloride/CFTR (cystic fibrosis), ciliary function and nasal nitric oxide, Aspergillus IgE and precipitins, rheumatoid factor, alpha-1 antitrypsin.
What our notes say
- Cause-finding: HIV test, immunoglobulins, sweat chloride/CFTR (cystic fibrosis), ciliary function and nasal nitric oxide, Aspergillus IgE and precipitins, rheumatoid factor, alpha-1 antitrypsin. (Bronchiectasis)
- cGMP= atrial natriuretic peptide (ANP), nitric oxide (NO) (Medical Physiology Assorted SAQs — With Answers (Past Paper Study Guide))
- Endothelial cell activation — activated by histamine, bradykinin, nitric oxide; paves way for cellular response (Medical MCQs: Chemical Pathology & Haematology Exam Review)
- Activation — leukocytes activated by resident tissue macrophages; phagocytose and conduct intracellular killing or generate ROS/nitric oxide for elimination (Medical MCQs: Chemical Pathology & Haematology Exam Review)
- Abdominal ultrasound/imaging — relevant to the presenting abdominal pain; PNH causes smooth muscle dystonia (free Hb scavenges nitric oxide) and predisposes to thrombosis (e.g. hepatic vein/Budd-Chiari) (Hematopathology MCQs & Essays: MBChB Exam Revision Guide)
- Cytokines involved: TGF-β (induces MMPs), TNF, prostaglandins, nitric oxide (Mastering Joint Pathology: Arthritis, OA & Joint Anatomy)
Practice questions on Nitric Oxide
Nitric oxide produces many of its physiologic effects by stimulating the synthesis of:
- Cyclic GMP (cGMP)
- Cyclic AMP (cAMP)
- Calmodulin
- Protein kinase A (PKA)
Answer: A. Nitric oxide (NO) is a signaling molecule that activates guanylate cyclase, an enzyme that catalyzes the production of cyclic guanosine monophosphate (cGMP) from GTP. cGMP then acts as a second messenger.
Complete Marked out of 1.00 Flag question Nitric oxide (NO) is a gas neurotransmitter that Select one:
- a. is synthesized in the nucleus.
- b. does not cross lipid membranes.
- c. dilates blood vessels.
- d. is transported to the synaptic terminals via microtubules.
- e. is stored in synaptic vesicles.
Answer: A.
Incorrect Mark 0.00 out of 1.00 Nitric oxide produces many of its physiologic effects by stimulating the synthesis of ---
- Cyclic GMP
- Cyclic AMP
- Calmodulin
- Protein kinase A
- Protein kinase C The correct answer is: Cyclic GMP
Answer: A.