Plasma Proteins
It is mainly due to plasma proteins referred to as oncotic pressure
What our notes say
- It is mainly due to plasma proteins referred to as oncotic pressure (Physio Y1 EOY 2021 — Past Paper Questions & Answers)
- Acute inflammation is a vascular and cellular response that aims at bringing more leukocytes and plasma proteins to the site of injury. (Medical MCQs: Chemical Pathology & Haematology Exam Review)
- Crescent formation in RPGN results from fibrin and plasma protein leakage into Bowman's space, stimulating parietal epithelial cell/macrophage proliferation (forming the "crescent"). (Male Reproductive & Urinary Tract Pathology MCQs | MKU Year 3 Medicine)
- So, plasma proteins from blood enter the tissues and inactivate the antigenic products (Medical Physiology Assorted SAQs — With Answers (Past Paper Study Guide))
- Allergic/anaphylactic reaction — recipient IgE-mediated hypersensitivity to donor plasma proteins (Medical MCQs: Chemical Pathology & Haematology Exam Review)
- Albumin - plasma protein concentrate; for hypoalbuminaemia, large-volume paracentesis, burns and nephrotic syndrome complications (Haematology End of Year 2025 Past Paper — MKU MBML 3200 Questions & Answers)
Study material on Plasma Proteins
- Blood Metabolites Measurement and Their Applications
- MBPL3621 Introduction to Pharmacology Quiz 1
- Blood Transfusion Medicine: An Exam-Focused Review
- Blood Biochemistry
- Medical MCQs: Chemical Pathology & Haematology Exam Review
- Blood Transfusion Guide: ABO, Reactions, Products & Safety
- Glomerular Diseases: Classification, Histology & Pathology
- Blood Metabolites Measurement and Plasma Proteins
- MBPL3621 Introduction to Pharmacology Quiz 1
Practice questions on Plasma Proteins
Which process is concerned with the blood brain barrier, tissue storage and plasma protein binding?
- Absorption
- Metabolism
- Distribution
- Excretion
Answer: C. Distribution involves the movement of drug from circulation to tissues and is affected by barriers (like blood-brain barrier), tissue binding, and plasma protein binding. --- ---
High plasma protein binding
- Facilitates glomerular filtration of the drug
- Increases volume of distribution of the drug
- Minimizes drug interactions
- Generally makes the drug long acting
- This prolongs drug action and half-lif
Answer: D. Drugs highly bound to plasma proteins act as a reservoir, slowly releasing free drug as it is eliminated. This prolongs drug action and half-life. --- ---
The plasma protein bound fraction of a drug
- Is not available for metabolism unless actively extracted by the liver
- Remains constant irrespective of the total drug concentration
- Remains constant irrespective of the disease state
- Contributes to the response at the given moment
Answer: A. Only free (unbound) drug is available for metabolism, distribution, and elimination. Protein-bound drug is pharmacologically inactive unless the liver can actively extract it. --- ---
The body's central metabolic clearinghouse, responsible for detoxifying various substances, synthesizing plasma proteins, and regulating nutrient levels in the blood, is known to be the:
- A. Kidney
- B. Spleen
- C. Liver
- D. Pancreas
Answer: C. The liver plays a central role in metabolism, processing nutrients absorbed from the gut, synthesizing numerous essential molecules, and detoxifying harmful substances, thus acting as the body's primary metabolic clearinghouse.
Which of the following plasma proteins has the highest affinity but lowest capacity for binding thyroxine (T4)? ---
- Transthyretin
- Albumin
- Thyroxine-binding globulin (TBG)
- Thyroxine-binding pre-albumin
Answer: A.