Pulmonary Capillary Leak

Also written as TRALI.

Transfusion‑related acute lung injury (TRALI) → donor anti‑HLA/HNA antibodies + recipient neutrophil activation → pulmonary capillary leak → non‑cardiogenic pulmonary edema.

What our notes say

• Transfusion‑related acute lung injury (TRALI) → donor anti‑HLA/HNA antibodies + recipient neutrophil activation → pulmonary capillary leak → non‑cardiogenic pulmonary edema. (Blood transfusion and reactions)
• | Respiratory | *Shortness of breath, cough, wheeze, or chest tightness?* | Pulmonary capillary leak (TRALI), bronchospasm (anaphylaxis), fluid overload. | (Blood transfusion and reactions)
• TRALI — donor antibodies react with recipient leukocyte antigens, causing pulmonary capillary leak (Medical MCQs: Chemical Pathology & Haematology Exam Review)
• Mechanism: donor anti-leukocyte antibodies react with recipient WBCs → pulmonary capillary leak (Renal, Liver, Cardiac & Adrenal Function Tests for Year 3)

Study material on Pulmonary Capillary Leak

• Blood transfusion and reactions
• Renal, Liver, Cardiac & Adrenal Function Tests for Year 3

Related topics

• Transfusion-Associated Circulatory Overload
• Transfusion-Related Acute Lung Injury
• Fasting Plasma Glucose
• Phaeochromocytoma
• Direct Antiglobulin Test
• Septic Shock
• Plasma Proteins
• Megaloblastic Anaemia
• Tumour Markers
• Acromegaly