Thrombocytopenia
d) Infection is typically associated with thrombocytopenia
What our notes say
- d) Infection is typically associated with thrombocytopenia (Junior Clerkship in Internal Medicine (MBIM4100) main exam, Paper One: 31 Januar)
- Essential thrombocythaemia is a high-platelet disorder. (The paper prints "thrombocytopenia", which is a typing error.) (Internal Medicine (MBIM 4100) main exam, Paper One: 3 July 2019)
- | Platelets | The range is unchanged (can fall slightly: gestational thrombocytopenia) | | (Physiological changes in pregnancy)
- In HIV-associated thrombocytopenia, autoantibodies are often \ (HEMATOLOGY EOY 2025 — Past Paper Questions & Answers)
- There is eczema, thrombocytopenia, and recurrent infection. (Immunopathology complete mcqs — Past Paper Questions & Answers)
- The blood film confirms the thrombocytopenia is genuine with no other abnormalities seen and review indicates that the preoperative platelet count was normal. (Haematology paper 1 Past Papers — Past Paper Questions & Answers)
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Practice questions on Thrombocytopenia
Blood product for thrombocytopenia with active bleeding?
- FFP
- Packed RBCs
- Cryoprecipitate
- Platelet concentrate
Answer: D. Thrombocytopenia = low platelets; replacing platelets directly addresses the bleeding cause. ---
Heparin-induced thrombocytopenia (HIT) typically occurs?
- Within 24 hours
- After 3 weeks
- 5–10 days after starting heparin
- Only with high-dose heparin
Answer: C. HIT is immune-mediated via antibodies against heparin-PF4 complexes. ---
A 28-year-old female at 32 weeks gestation presents with schistocytic anemia, thrombocytopenia, and normal coagulation studies. ADAMTS13 is 45%. BP is 160/110 mmHg, urinalysis shows 3+ protein. What is the most likely diagnosis?
- Thrombotic Thrombocytopenic Purpura (TTP)
- Hemolytic Uremic Syndrome (HUS)
- HELLP Syndrome
- Disseminated Intravascular Coagulation (DIC)
Answer: C. HELLP (Hemolysis, Elevated Liver enzymes, Low Platelets) is confirmed by the pregnancy context, hypertension, and proteinuria. ADAMTS13 >10% rules out TTP. Normal coagulation rules out DIC. ---
Which of the following blood components is indicated in a patient with thrombocytopenia and active bleeding?
- Fresh frozen plasma
- Cryoprecipitate
- Red blood cells
- Platelet concentrate
Answer: D. Platelet concentrate directly replaces the deficient platelets responsible for bleeding in thrombocytopenia. ---
In HIV-associated thrombocytopenia, autoantibodies are often directed against which platelet antigen?
- Glycoprotein Ib/IX
- Glycoprotein IIb/IIIa
- Human platelet antigen-1
- CD4
Answer: B. As in classic immune thrombocytopenia, autoantibodies most commonly target the GPIIb/IIIa complex on the platelet surface. ---
Blood product for thrombocytopenia with active bleeding ---
- Fresh frozen plasma
- Packed red blood cells
- Platelet concentrate Directly replaces the deficient platelets.
- Cryoprecipitate
- Albumin Answer:
Answer: A.