Cell Cycle Control

E6 protein binds to and promotes degradation of the p53 tumor suppressor protein → loss of cell cycle control and apoptosis.

What our notes say

• E6 protein binds to and promotes degradation of the p53 tumor suppressor protein → loss of cell cycle control and apoptosis. (Female rep y3 — Past Paper Questions & Answers)
• E7 degrades Rb (retinoblastoma protein) → loss of cell cycle control (General Pathology Revision: Cell Injury, Inflammation & Adaptation (MBPA 3500 Pa)
• HPV (cause of condyloma acuminata/genital warts) uses E6/E7 oncoproteins to degrade p53 and Rb respectively, disrupting normal cell cycle control. (Male Reproductive & Urinary Tract Pathology MCQs | MKU Year 3 Medicine)
• | HTLV-1 (retrovirus, often grouped here) | Adult T-cell leukemia/lymphoma | Tax protein interferes with cell cycle control | (Medical Virology: Hepatitis, Viral Carcinogenesis & Oncogenic Viruses)
• Viral oncoproteins E6 (degrades p53) and E7 (inactivates Rb) → loss of cell cycle control (General & Systemic Pathology SAQ — Paper II)
• | Latent infection | Viral cyclin D (v-cyclin) homologue | Disrupts p21/p27 cell cycle controls | (VASCULAR PATHOLOGY — Must-Know Comprehensive Notes)

Study material on Cell Cycle Control

• TUMOR SUPPRESSOR GENES & CELL CYCLE CONTROL MCQs

Related topics

• Cell Cycle
• Hydronephrosis
• Bladder Cancer
• Carcinogenesis
• Systemic Pathology
• Tumor Suppressor Genes
• Apoptosis
• Cervical Intraepithelial Neoplasia
• Atherosclerosis
• Filariasis