Oesophageal Cancer
Which oesophageal cancer is strongly associated with synergistic alcohol and tobacco use and typically affects the middle 1/3 of the oesophagus? → Oesophageal Squamous Cell Carcinoma.
What our notes say
- Which oesophageal cancer is strongly associated with synergistic alcohol and tobacco use and typically affects the middle 1/3 of the oesophagus? → Oesophageal Squamous Cell Carcinoma. (Gastrointestinal Neoplasms: High-Yield Exam Review)
- Indirect-acting (procarcinogens): require metabolic activation (usually by cytochrome P450) - polycyclic aromatic hydrocarbons in tobacco smoke (lung cancer), aflatoxin B1 (hepatocellular carcinoma), aromatic amines (bladder cancer), nitrosamines (gastric/oesophageal cancer). (Eoy paper 2 gen systemic Patho 2025 — Past Paper Questions & Answers)
- Oesophageal Cancer — dysphagia, weight loss, chest pain; subtypes: squamous cell and adenocarcinoma (CRUSH COURSE (PART 2) Clinical Chem Patho)
- Nitrosamines (e.g. in processed meats) → gastric, oesophageal cancer (General & Systemic Pathology SAQ — Paper II)
- Can indicate oesophageal cancer or cancer of the gastric cardia/fundus. (Gastrointestinal System: Symptoms, Diseases, & VINDICATE Guide)
- ✦ Alcohol reduction → reduces liver, breast, colorectal, oesophageal cancer risk (Molecular Basis of Cancer: Cell Cycle, Apoptosis & Angiogenesis)