Cell Injury
Results from severe cell injury and is irreversible, unlike apoptosis.
What our notes say
- Results from severe cell injury and is irreversible, unlike apoptosis. (General Pathology I)
- One of the following is a feature of reversible cell injury: (Medical MCQs: Chemical Pathology & Haematology Exam Review)
- Granulation tissue is composed mainly of Collagen III, produced by fibroblasts following cell injury to repair tissue (Medical MCQs: Chemical Pathology & Haematology Exam Review)
- All other morphologic changes listed are associated with reversible cell injury, in which the cell membrane remains intact. (Cellular Injury and Adaptation MCQs)
- b) Necrosis: Pathologic cell death resulting from severe cell injury, characterized by cellular swelling, membrane disruption, organelle dysfunction, and release of cellular contents causing inflammation. (general Pathology Q&A)
- (b) Inflammation and acinar cell injury release pancreatic enzymes, including amylase, into the blood. (Chemical Pathology Practice Examination)
Study material on Cell Injury
- General Pathology Revision: Cell Injury, Inflammation & Adaptation (MBPA 3500 Paper 1)
- Pathology CAT 1: Cell Injury, Metaplasia & Hypoxia Q&A
- General Pathology I
- Medical MCQs: Chemical Pathology & Haematology Exam Review
- General Pathology I
- Cell Injury, Adaptation & Death.
- Cell Injury & Adaptation
- PATHOLOGY MCQs: CELL INJURY, DEATH, AND ADAPTATIONS
- Pathology MCQs: Cell Injury, Cell Death, and Adaptations
- Cell injury mcqs — Past Paper Questions & Answers
- 50 Multiple Choice Questions
Practice questions on Cell Injury
A 44-year-old man has a history of poorly controlled diabetes mellitus leading to coronary artery disease. He now has decreasing cardiac output. An increase in which of the following substances in his blood is most indicative of reversible cell injury from decreased perfusion of multiple organs and tissues?
- Carbon dioxide
- Creatinine
- Glucose
- Lactic acid
- Troponin I ANSWER: D
Answer: D. Decreased tissue perfusion leads to hypoxemia and depletion of ATP when cell metabolism shifts from aerobic to anaerobic glycolysis, resulting in depletion of glycogen stores and increased production and accumulation of lactic acid, reducing intracellular pH. ---
Which is the most common cause of cell injury in clinical medicine?
- Immunologic reactions
- Hypoxia and ischemia
- Genetic defects
- Nutritional imbalances
Answer: B. Hypoxia and ischemia are the most common causes of cell injury, underlying conditions like myocardial infarction, stroke, and tissue infarcts throughout the body. --- ---
The earliest ultrastructural change in reversible cell injury is
- Nuclear pyknosis
- Mitochondrial swelling
- Plasma membrane rupture
- Lysosomal rupture
Answer: B. Mitochondrial swelling and formation of amorphous densities in the mitochondrial matrix are among the earliest ultrastructural changes in reversible cell injury, reflecting impaired oxidative phosphorylation. --- ---
The hallmark of irreversible cell injury is
- Cellular swelling
- Fatty change
- Inability to reverse mitochondrial dysfunction
- Ribosomal detachment
Answer: C. The point of no return in cell injury is marked by the inability to restore mitochondrial function even after resolution of the original injury. This leads to progressive loss of membrane integrity and cell death. --- ---
Which is the most common cause of cell injury in clinical medicine?
- Immunologic reactions
- Hypoxia and ischemia
- Genetic defects
- Nutritional imbalances
Answer: B. Hypoxia and ischemia are the most common causes of cell injury, underlying conditions like myocardial infarction, stroke, and tissue infarcts throughout the body. --- ---
The earliest ultrastructural change in reversible cell injury is
- Nuclear pyknosis
- Mitochondrial swelling
- Plasma membrane rupture
- Lysosomal rupture
Answer: B. Mitochondrial swelling and formation of amorphous densities in the mitochondrial matrix are among the earliest ultrastructural changes in reversible cell injury, reflecting impaired oxidative phosphorylation. --- ---